ABSTRACT
<p><b>OBJECTIVE</b>To investigate the influences of total abdominal and laparoscopically hysterectomy on coagulation and fibrinolytic functions.</p><p><b>METHODS</b>Blood samples were taken from 20 patients without high-risk factor of thrombosis before and after total abdominal and laparoscopically hysterectomy. The values of PT, APTT, FG, D-Dimer and AT-III were measured.</p><p><b>RESULTS</b>The values of PT and AT-III significantly decreased while D-Dimer significantly increased after the operations. These changes were more obvious in patients undergoing abdominal hysterectomy. No significant changes in APTT or FG were noted after hysterectomy.</p><p><b>CONCLUSIONS</b>Patients undergoing hysterectomy are at risk of developing thromboembolism, but the laparoscopic approach can significantly lower this risk as compared with abdominal hysterectomy.</p>
Subject(s)
Female , Humans , Blood Coagulation Tests , Hysterectomy , Methods , Laparoscopy , Partial Thromboplastin Time , Risk Factors , Thromboembolism , DiagnosisABSTRACT
<p><b>OBJECTIVE</b>To detect the expression of fragile histidine triad in endometriosis and investigate the pathogenesis of endometriosis.</p><p><b>METHODS</b>immunohistochemistry was used to examine the expression of Fhit in the eutopic and ectopic endometria of 58 patients with endometriosis and in the endometria in 15 patients with hysteromyoma.</p><p><b>RESULTS</b>The intensity of Fhit expression decreased in the order of normal endometrium, eutopic endometrium in endometriosis group, and ectopic endometrium. In patients with endometriosis, Fhit expression in the eutopic and ectopic endometria in proliferative phase showed no significant difference from that in secretory phase (P>0.05). Fhit expression in the ectopic endometrium showed significant difference between different r-AFS stages. MOD of ectopic endometrium in stages I-II was significantly higher than that in stages III-IV (P<0.05), but Fhit expression in the eutopic endometrium showed no significant difference (P>0.05). MOD of ovarian endometriosis showed no difference with that of adenomyosis.</p><p><b>CONCLUSIONS</b>Fhit may play an important role in the development of endometriosis.</p>